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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T37048 |
MMP-3 Inhibitor
|
MMP | Proteases/Proteasome |
MMP-3 Inhibitor 是一种多肽基质金属蛋白酶-3(MMP-3)抑制剂,Ki 值为 95 nM。MMP-3 inhibitor 具有抗癌抗肿瘤活性。 | |||
T37048L |
MMP-3 Inhibitor acetate
MMP-3 Inhibitor acetate(158841-76-0 Free base) |
MMP | Proteases/Proteasome |
MMP-3 Inhibitor acetate 是一种细胞渗透性强的人 MMP-3 抑制剂. | |||
T16124 |
MMP13-IN-3
|
MMP | Proteases/Proteasome |
MMP13-IN-3 是口服有效的MMP-13选择性抑制剂,IC50为 1 nM,比其他 MMP 的选择性高 1000倍多。MMP13-IN-3在用于骨关节炎方面有研究的价值。 | |||
T15574 |
Incyclinide
COL-3,CMT-3 |
MMP | Proteases/Proteasome |
Incyclinide (COL-3) 是一种基质金属蛋白酶 (MMP) 抑制剂,能够诱导细胞外基质降解,抑制血管生成,肿瘤生长和侵袭以及转移。 | |||
T12082 |
MMP3 inhibitor 1
|
MMP | Proteases/Proteasome |
MMP3 inhibitor 1 is a potent and highly selective inhibitor of MMP-3 (IC50 of 1 nM). | |||
T20563 |
PD-166793
PD-166793-0000,PD 166793,PD166793 |
MMP | Proteases/Proteasome |
PD-166793是一种具有口服活性、有效性和选择性的 MMP 抑制剂,对 MMP-2,MMP-3 和 MMP-13 具有抑制作用。PD-166793 在大鼠心力衰竭模型中改善心肌缺血和再灌注损伤。 | |||
T61271 |
MMP2-IN-3
|
MMP | Proteases/Proteasome |
MMP2-IN-3是一种有效的基质金属蛋白酶(MMP-2)抑制剂( IC50 值:31 μM)。MMP2-IN-3 抑制 MMP-9 和 MMP-8 ,其 IC50 分别为 26.6 和 32 μM。 | |||
T36712 |
BPHA
MMP-2/MMP-9 Inhibitor II |
MMP | Proteases/Proteasome |
BPHA (MMP-2/MMP-9 Inhibitor II) 是一种有效的、具有选择性和口服活性的抑制剂,对MMP-2、MMP-9 和 MMP-14 具有抑制作用,IC50 分别为 12 nM、16 nM 和 17 nM。BPHA 不抑制 MMP-1、-3 和 -7 (IC50 分别为 974、>1000 和 795 nM)。BPHA 具有抗血管生成和抗肿瘤活性。 | |||
T14322 |
ARP-100
MMP-2 Inhibitor III |
MMP | Proteases/Proteasome |
ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM),MMP-3 (4.5 μM),MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1'口袋相互作用,并在体外对基质胶的侵袭模型中显示抗侵袭特性。 | |||
T6011 |
Batimastat
巴马司他,BB94 |
MMP | Proteases/Proteasome |
Batimastat (BB94) 是广谱MMP 抑制剂,能够抑制MMP-1 (IC50:3 nM),MMP-2 (IC50:4 nM),MMP-9 (IC50:4 nM),MMP-7 (IC50:6 nM) 和 MMP-3 (IC50:20 nM)。 | |||
T6885 |
Marimastat
BB2516,马立马司他,KB-R8898,TA2516 |
MMP | Proteases/Proteasome |
Marimastat (BB2516) 是一种血管生成和转移抑制剂,限制血管的生长和生成。它是一种广谱的,具有口服活性的MMPs 抑制剂,有效抑制 MMP-9 , MMP-1, MMP-2, MMP-14, MMP-7,用于癌症的研究。 | |||
T2743 |
Ilomastat
Galardin,GM6001,伊洛马司他 |
MMP | Proteases/Proteasome |
Ilomastat (GM6001) 是广谱的基质金属蛋白酶 (MMP) 抑制剂,可抑制 MMP 的活性,IC50值分别为 1.5 nM (MMP-1),1.1 nM (MMP-2),1.9 nM (MMP-3),0.5 nM (MMP-9),对人皮肤成纤维细胞胶原酶 (MMP-1) 的Ki=为 0.4 nM。 | |||
T5416 |
T-5224
|
MMP | Proteases/Proteasome |
T-5224 是选择性的转录因子c-Fos/activator protein (AP)-1抑制剂,具有抗炎作用,能够特异性抑制 c-Fos/c-Jun 的 DNA 结合活性,但对其他转录因子的结合活性无影响。它抑制 IL-1β 诱导的 Mmp-3、Mmp-13、Adamts-5 转录上调。 | |||
T10461 |
Batimastat sodium salt
BB-94 sodium salt |
MMP | Proteases/Proteasome |
Batimastat (BB-94) sodium salt is a broad-spectrum MMP inhibitor (IC50s: 3, 4, 4, 6, and 20 nM for MMP-1, MMP-2, MMP-9, MMP-7, and MMP-3). | |||
T36962 |
MMP Inhibitor I (trifluoroacetate salt)
|
||
MMP inhibitor I is a peptide inhibitor of matrix metalloproteinase-1 (MMP-1), MMP-2, and MMP-3 (IC50s = 1.3, 30, and 150 μM, respectively). It is selective for MMP-1, MMP-2, and MMP-3 over the proteases thermolysin, urease, trypsin, α-chymotrypsin, plasmin, and elastase at concentrations up to 4 mM. | |||
T29150 |
WAY-151693
WAY151693,WAY 151693 |
||
WAY-151693 is an inhibitor of human collagenase-3 (MMP-13). | |||
T13249 |
UK-370106
|
MMP | Proteases/Proteasome |
UK-370106 is a potent and highly selective inhibitor of MMP-3 with IC50 of 23 nM and MMP-12 with IC50 of 42 nM, and potently inhibits cleavage of [3H]-fibronectin by MMP-3 (IC50: 320 nM). | |||
T23206 |
PTIQ
|
Others | Others |
MMP-3 expression inhibitor | |||
T13358 |
XL-784
|
MMP | Proteases/Proteasome |
XL-784 is a selective inhibitor of matrix metalloproteinases (MMP)(IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively). | |||
T12539 |
Prinomastat hydrochloride
KB-R9896 hydrochloride,AG3340 hydrochloride |
MMP | Proteases/Proteasome |
Prinomastat hydrochloride is a orally active inhibitor of metalloproteinase (MMP)(MMP-1, MMP-3 and MMP-9 with IC50s of 79, 6.3 and 5.0 nM , respectively),with Antitumor avtivity. | |||
T70011 |
PNU-142372
|
||
PNU-142372 is an MMP-3 inhibitor. | |||
T16986 |
Tanomastat
BAY 12-9566 |
MMP | Proteases/Proteasome |
Tanomastat is an orally bioavailable and non-peptidic biphenyl matrix metalloproteinases inhibitor. For MMP-2, MMP-3, MMP-9, MMP-13 the Ki values are 11, 143, 301, and 1470 nM respectively. | |||
T24775 |
SD-2590 HCl
SD2590 HCl,SD-2590 Hydrochloride,SD2590 Hydrochloride,SD 2590 Hydrochloride |
||
SD-2590 HCl is an MMP-2,-3, -9, -8, 13, and -14 inhibitor. | |||
T22685 |
CP-471474
CP 471474 |
Others | Others |
Broad spectrum MMP inhibitor (IC<sub>50</sub> values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively). Attenuates early left ventricular dilation after experimental myocardial infarction in mice. | |||
T37983 |
GM 1489
|
||
GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2'-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phor... | |||
T63155 |
MMP-9-IN-3
|
||
MMP-9-IN-3 是一种 MMP-9 抑制剂 (IC50: 5.56 nM),可与 MMP-9 形成氢键。MMP-9-IN-3 对 AKT 的活性具有抑制作用 (IC50: 2.11 nM)。MMP-9-IN-3 具有细胞毒性,能够诱导细胞凋亡。MMP-9-IN-3 能够用于研究癌症。 | |||
T13357 |
XL-784 free base
|
Others | Others |
XL-784 free base is a selective inhibitor of matrix metalloproteinases (MMP), (IC50s of ~1900, 0.81, 120, 10.8, 18, 0.56 nM for MMP-1,MMP-2,MMP-3,MMP-8,MMP-9,MMP-13,respectively). | |||
T12539L |
Prinomastat
KB-R9896,普啉司他,AG3340 |
MMP | Proteases/Proteasome |
Prinomastat inhibits MMP-2, MMP-3 and MMP-9 (Kis: 0.05 nM, 0.3 nM and 0.26 nM, respectively). Prinomastat crosses the blood-brain barrier. It also has antitumor activity. Prinomastat is a broad-spectrum, potent, orally active metalloproteinase inhibitor ( | |||
T81778 |
MMP-7-IN-3
|
MMP | Proteases/Proteasome |
MMP-7-IN-3为一种高效MMP-7选择性抑制剂,能够在单侧输尿管梗阻的小鼠模型中阻止肾纤维化的发展。 | |||
T81777 |
MMP-9-IN-8
|
||
MMP-9-IN-8(Compound 3)是MMP-9抑制剂,10 μM浓度下抑制活性为42.16%,50 μM时达58.28%。该化合物展现抗癌活性,能诱导MCF-7细胞凋亡,IC50为23.42 μM。 | |||
T72719 | Tubulin/MMP-IN-2 | ||
Tubulin/MMP-IN-2是一种针对微管蛋白和基质金属蛋白酶的双重抑制剂,能有效抑制微管蛋白聚合并触发细胞凋亡。该化合物对MMP-2、MMP-3及MMP-9展现出明显的抑制效果,其IC50值分别为24.95 μM、31.60 μM与22.37 μM。Tubulin/MMP-IN-2主要应用于癌症研究领域。 | |||
T63545 | FAK-IN-3 | ||
FAK-IN-3 是一种有效的粘着斑激酶 (FAK) 抑制剂。FAK-IN-3 能够减少 PA-1 细胞的迁移和侵袭,并抑制 MMP-2 和 MMP-9 的表达。FAK-IN-3 对肿瘤生长和转移具有抑制作用,且没有明显不良反应。FAK-IN-3 对卵巢癌表现出研究潜力。 | |||
T62090 |
(Rac)-Tanomastat
|
||
Rac)-Tanomastat ((Rac)-BAY 12-9566) 是 Tanomastat 的外消旋体。其中 Tanomastat (BAY 12-9566) 是一种口服具有活力的、含锌羧基的非肽联苯基质金属蛋白酶(MMPs)抑制剂,能够抑制 MMP-2 (Ki: 11 nM)、MMP-3 (Ki: 143 nM)、MMP-9 (Ki: 301 nM)、MMP-13 (Ki: 1470 nM)。在几种实验性肿瘤模型中,Tanomastat 表现出抗侵袭和抗转移作用。 | |||
T21735 |
NNGH
|
||
NNGH 是基质分解素-1 (MMP-3) 抑制剂。 MMP-3 既是直接转录靶蛋白,也是 Wnt/β-catenin 信号通路的必要组成。 基质金属蛋白酶 (MMP) 在肿瘤进展的晚期发挥着明确的作用。 | |||
T41079 |
MMP13-IN-2
MMP13-IN-2 |
||
MMP13-IN-2 is a highly potent, selective, and orally active inhibitor of MMP-13. It demonstrates exceptional potency against MMP-13, with an IC50 value of 0.036 nM, and exhibits selectivities greater than 1,500-fold over MMP-1, 3, 7, 8, 9, 14, and TACE. Moreover, MMP13-IN-2 possesses the capability to effectively inhibit collagen release from cartilage in vitro. Consequently, MMP13-IN-2 holds great potential for advancing research on collagenase-related diseases. | |||
T82022 | IVMT-Rx-3 | NF-κB | NF-κB |
IVMT-Rx-3是针对SDCBP的PDZ1和PDZ2结构域,特别是MDA-9/Syntenin的抑制剂。该化合物能够中断MDA-9/Syntenin与Src之间的互动,减少NF-κB的激活,并且降低MMP-2/MMP-9的表达量,从而抑制了黑色素瘤的转移。 | |||
T75432 | Doxycycline calcium | ||
Doxycycline calcium,一种具口服活性的四环素类抗生素,同时为广谱金属蛋白酶(MMP)抑制剂,展现出抗菌及抗肿瘤细胞增殖的活性。 | |||
T36844 |
Inostamycin A
|
||
Inostamycin A is a bacterial metabolite that has been found inStreptomycesand has anticancer activity.1It is an inhibitor of CDP-diacylglycerol:inositol 3-phosphatidyltransferase (IC50= 0.02 μg/ml in A431 cell membranes) and is selective for CDP-diacylglycerol:inositol 3-phosphatidyltransferase over phospholipase C (PLC) and phosphatidylinositol kinase at 10 μg/ml.2Inostamycin A decreases viability of YCU-T892, KCC-TC873, KB, HSC-4, and YCU-T891 oral squamous cell carcinoma (OSCC) cells in a con... | |||
T68321 |
AS1940477
|
||
AS1940477 is p38 MAPK inhibitor. AS1940477 inhibited the enzymatic activity of recombinant p38α and β isoforms but showed no effect against other 100 protein kinases including p38γ and δ isoforms. In human peripheral blood mononuclear cells, AS1940477 inhibited lipopolysaccharide (LPS)- or phytohemagglutinin A (PHA)-induced production of proinflammatory cytokines, including TNFα, IL-1β, and IL-6 at low concentrations (LPS/TNFα, IC(50)=0.45n M; PHA/TNFα, IC(50)=0.40 nM). In addition, equivalent c... | |||
T37861 | Talabostat | ||
Talabostat (PT100, Val-boroPro) is a potent, nonselective and orally available dipeptidyl peptidase IV (DPP-IV) inhibitor with a Ki of 0.18 nM. Talabostat is a nonselective DPP-IV inhibitor, inhibiting DPP8/9, FAP, DPP2 and some other DASH family enzymes essentially as potently as it inhibits DPP-IV[1]. Talabostat stimulates the immune system by triggering a proinflammatory form of cell death in monocytes and macrophages known as pyroptosis. The inhibition of two serine proteases, DPP8 and DPP9,... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2993 |
Cordycepin
3'-Deoxyadenosine,虫草素 |
MMP; TNF; Antibacterial; Antibiotic; Autophagy | Apoptosis; Autophagy; Microbiology/Virology; Proteases/Proteasome |
Cordycepin (3'-Deoxyadenosine) 是一种核苷衍生物,在类风湿性关节炎滑膜成纤维细胞中,剂量依赖性抑制 IL-1β 诱导的 MMP-1和 MMP-3表达。它也抑制细菌的腺苷激酶从而抗结核分枝杆菌。 | |||
T2769 |
3-Aminopropionitrile fumarate (2:1)
Di-β-aminopropionitrile fumarate,3-Aminopropionitrile fumarate,3-氨基丙腈,β-Aminopropionitrile fumarate,3-Aminopropionitrile fumarate 2:1,Beta-Aminopropionitrile fumarate,β-Ammoniumpropionitrile hemifumarate |
Others | Others |
3-Aminopropionitrile fumarate (2:1) (β-Aminopropionitrile fumarate) 是一种能抑制胶原蛋白(collagen)交联的山黧豆素。 | |||
T14121 |
Actinonin
(-)-Actinonin |
Aminopeptidase | Metabolism |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5]. | |||
TN4046 | Excisanin A | MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK | Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors |
ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ... |